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Bianco, Antonio

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overview	Antonio Bianco is a physician-scientist working in the thyroid field. His studies have focused on how the systemic hormone T3 initiates or terminates critical biological steps while maintaining relatively stable levels in the circulation. As a graduate student, he discovered the molecular link between deiodination and thermogenesis, specifically that the UCP-1 gene, key for brown adipose tissue thermogenesis, is transcriptionally stimulated by T3. This finding inspired further research on how deiodinases can modify intracellular T3 levels and signaling without antecedent changes in plasma TH levels. Over the years, the work in his lab has established the importance of “local” control of TH metabolism provided by deiodinases. From a broad perspective, this work has inspired the modern paradigm that deiodinases regulate thyroid hormone signaling on a tissue-specific basis, playing critical roles in human health and disease. He also served in different administrative capacities and as President of the American Thyroid Association (2015-16).

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overview

Antonio Bianco is a physician-scientist working in the thyroid field. His studies have focused on how the systemic hormone T3 initiates or terminates critical biological steps while maintaining relatively stable levels in the circulation. As a graduate student, he discovered the molecular link between deiodination and thermogenesis, specifically that the UCP-1 gene, key for brown adipose tissue thermogenesis, is transcriptionally stimulated by T3. This finding inspired further research on how deiodinases can modify intracellular T3 levels and signaling without antecedent changes in plasma TH levels. Over the years, the work in his lab has established the importance of “local” control of TH metabolism provided by deiodinases. From a broad perspective, this work has inspired the modern paradigm that deiodinases regulate thyroid hormone signaling on a tissue-specific basis, playing critical roles in human health and disease. He also served in different administrative capacities and as President of the American Thyroid Association (2015-16).

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Item Type	Name
Concept	Acetates
Concept	Adenocarcinoma
Concept	Adrenal Cortex Neoplasms
Concept	Adrenalectomy
Concept	Alcoholism
Concept	Academic Medical Centers
Concept	Acclimatization
Concept	Amygdala
Concept	Antibiotics, Antineoplastic
Concept	Aortic Valve Stenosis
Concept	Arcuate Nucleus of Hypothalamus
Concept	Adaptation, Physiological
Concept	Adenylyl Cyclases
Concept	Calcium-Transporting ATPases
Concept	Cyclic AMP
Concept	Acetylcysteine
Concept	Adenosine Triphosphatases
Concept	Birds
Concept	Bile Acids and Salts
Concept	Brain Diseases
Concept	Alleles
Concept	Amino Acid Sequence
Concept	Alcohol Dehydrogenase
Concept	Energy Intake
Concept	Cerebral Cortex
Concept	Animals, Newborn
Concept	Carbon Dioxide
Concept	Sterol Esterase
Concept	Basal Metabolism
Concept	Base Sequence
Concept	Cell Count
Concept	Cell Nucleus
Concept	Benzoates
Concept	Body Weight
Concept	Brain Diseases, Metabolic
Concept	Carcinoma, Non-Small-Cell Lung
Concept	Cell Membrane
Concept	Caffeic Acids
Concept	Carcinoma 256, Walker
Concept	Chromans
Concept	Cerebral Ventricles
Concept	Cholesterol, Dietary
Concept	Cardiomyopathy, Restrictive
Concept	Citric Acid Cycle
Concept	Chicago
Concept	Cold Temperature
Concept	Cardiotonic Agents
Concept	Golgi Apparatus
Concept	Computer Systems
Concept	Cholesterol
Concept	Clathrin
Concept	Coronary Artery Disease
Concept	Corticosterone
Concept	Dementia
Concept	Demography
Concept	Diabetes Mellitus, Type 1
Concept	Diabetes Mellitus, Type 2
Concept	Cysteine
Concept	Dactinomycin
Concept	Cycloheximide
Concept	Cysteine Endopeptidases
Concept	Cytological Techniques
Concept	Cytoplasm
Concept	Dexamethasone
Concept	Diet
Concept	Insulin
Concept	Coumaric Acids
Concept	Disulfides
Concept	Dithiothreitol
Concept	Catecholamines
Concept	Cerebral Hemorrhage
Concept	Fatty Liver, Alcoholic
Concept	Isoproterenol
Concept	Lac Operon
Concept	Endoplasmic Reticulum
Concept	Hypothalamo-Hypophyseal System
Concept	Iduronidase
Concept	Cross-Sectional Studies
Concept	Disease Susceptibility
Concept	Dobutamine
Concept	Eating
Concept	Colforsin
Concept	Faculty, Medical
Concept	Genes
Concept	Glial Fibrillary Acidic Protein
Concept	Fasting
Concept	Fatty Acids
Concept	Growth Plate
Concept	Hippocampus
Concept	Histocytochemistry
Concept	Heart Failure
Concept	Embryo, Mammalian
Concept	Dopamine
Concept	Energy Metabolism
Concept	Epithelium
Concept	Enzyme Induction
Concept	Feedback
Concept	Flow Cytometry
Concept	Fluorescent Antibody Technique
Concept	Infusions, Intravenous
Concept	Glycoside Hydrolases
Concept	Medicare
Concept	Leukocytes
Concept	Myocardial Infarction
Concept	Estrogens
Concept	Immunohistochemistry
Concept	Injections, Intraventricular
Concept	Organ Size
Concept	Molecular Sequence Data
Concept	NADP
Concept	Graves Disease
Concept	Ovariectomy
Concept	Oxidative Phosphorylation
Concept	Cricetinae
Concept	Hot Temperature
Concept	Heat-Shock Proteins
Concept	HeLa Cells
Concept	Paraventricular Hypothalamic Nucleus
Concept	Neutrophils
Concept	Phenylbutyrates
Concept	Oxidation-Reduction
Concept	Selenium
Concept	Endopeptidases
Concept	Pituitary Gland, Anterior
Concept	Physical Conditioning, Animal
Concept	Muscle Proteins
Concept	Oxygen
Concept	Feeding Behavior
Concept	Femur
Concept	Thyroidectomy
Concept	Tibia
Concept	Physostigmine
Concept	Pituitary Gland
Concept	Puromycin Aminonucleoside
Concept	Histone Deacetylases
Concept	Glucose Tolerance Test
Concept	Repressor Proteins
Concept	Iodine
Concept	Retinoids
Concept	Interleukin-6
Concept	Sweetening Agents
Concept	Hospitals
Concept	Sympathectomy
Concept	Body Mass Index
Concept	Incidence
Concept	Transcription, Genetic
Concept	Protein Biosynthesis
Concept	Tretinoin
Concept	CHO Cells
Concept	Critical Illness
Concept	Syndrome
Concept	Hypertrophy, Right Ventricular
Concept	Sequence Homology, Amino Acid
Concept	Taurochenodeoxycholic Acid
Concept	Androstane-3,17-diol
Concept	Iodine Radioisotopes
Concept	Carcinoma, Neuroendocrine
Concept	Weight Loss
Concept	Trans-Activators
Concept	Relative Value Scales
Concept	Postprandial Period
Concept	Middle Cerebral Artery
Concept	Tumor Cells, Cultured
Concept	NF-kappa B
Concept	Collagen Type X
Concept	Eukaryotic Initiation Factor-2
Concept	Glucose Clamp Technique
Concept	Lipid Peroxidation
Concept	Mitochondria
Concept	Weight Gain
Concept	Proto-Oncogene Proteins c-fos
Concept	Gene Expression
Concept	Proto-Oncogene Proteins c-myc
Concept	Case-Control Studies
Concept	RNA Interference
Concept	In Situ Hybridization
Concept	Genes, Reporter
Concept	Metoclopramide
Concept	Myelin Sheath
Concept	Ubiquitin Thiolesterase
Concept	Parathyroid Hormone-Related Protein
Concept	MyoD Protein
Concept	Efficiency, Organizational
Concept	Cell Proliferation
Concept	Ventricular Dysfunction
Concept	Patient-Centered Care
Concept	Disease Progression
Concept	Thapsigargin
Concept	Receptors, Adrenergic, beta-2
Concept	Pituitary Adenylate Cyclase-Activating Polypeptide
Concept	Myosin Heavy Chains
Concept	Prefrontal Cortex
Concept	Orphan Nuclear Receptors
Concept	Adrenergic beta-1 Receptor Agonists
Concept	Adenylate Cyclase Toxin
Concept	PPAR gamma
Concept	Paired Box Transcription Factors
Concept	Hypoxia-Inducible Factor 1, alpha Subunit
Concept	Proteasome Endopeptidase Complex
Concept	Palmitic Acid
Concept	Cholic Acid
Concept	Response Elements
Concept	Songbirds
Concept	Internet
Concept	Leptin
Concept	Evidence-Based Medicine
Concept	Lactic Acid
Concept	Catalytic Domain
Concept	STAT3 Transcription Factor
Concept	Phosphoenolpyruvate Carboxykinase (GTP)
Concept	Promoter Regions, Genetic
Concept	Adipocytes, Brown
Concept	Thyrotrophs
Concept	Endosomes
Concept	Hedgehog Proteins
Concept	Sarcoplasmic Reticulum
Concept	Seminiferous Epithelium
Concept	HEK293 Cells
Concept	Cognitive Dysfunction
Concept	Chalcones
Concept	Subcellular Fractions
Concept	Vitamin D
Concept	Insulin-Secreting Cells
Concept	Temperature
Concept	Zinc
Concept	Blotting, Western
Concept	HSP40 Heat-Shock Proteins
Concept	Thiolester Hydrolases
Concept	Transcription Factor RelA
Concept	Absorptiometry, Photon
Concept	Hyperandrogenism
Concept	Cell Hypoxia
Concept	Receptors, Adrenergic, beta-1
Concept	DNA Methylation
Concept	GTP-Binding Proteins
Concept	Dimerization
Concept	Stroke
Concept	Adrenergic Antagonists
Concept	Cell Lineage
Concept	Two-Hybrid System Techniques
Concept	Diabetes Complications
Concept	History, 20th Century
Concept	STAT5 Transcription Factor
Concept	Myogenic Regulatory Factor 5
Concept	Transcriptome
Concept	Agouti Signaling Protein
Concept	Cyclic AMP-Dependent Protein Kinase Type II
Concept	Insulin Receptor Substrate Proteins
Concept	Hep G2 Cells
Concept	Precision Medicine
Concept	Kaempferols
Concept	Cell Line, Tumor
Concept	Forkhead Transcription Factors
Concept	Agouti-Related Protein
Concept	Drug Discovery
Concept	Diet, High-Fat
Concept	Alzheimer Disease
Concept	Immunotoxins
Concept	Axons
Concept	Blood Chemical Analysis
Concept	Bone Resorption
Concept	Calcium
Concept	Cell Line
Concept	Cells, Cultured
Concept	Brain Ischemia
Concept	Chickens
Concept	Chromatin
Concept	Cimetidine
Concept	Dietary Fats
Concept	Digitonin
Concept	Disease Models, Animal
Concept	Doxorubicin
Concept	Epidermis
Concept	Fluorescent Dyes
Concept	Follow-Up Studies
Concept	Gestational Age
Concept	Hypothalamus
Concept	Hypothalamus, Middle
Concept	Longitudinal Studies
Concept	Membrane Potentials
Concept	Norepinephrine
Concept	Prospective Studies
Concept	Receptors, Adrenergic, beta
Concept	Retrospective Studies
Concept	Tropomyosin
Concept	Gastric Bypass
Concept	Hospital Mortality
Concept	Cyclic AMP-Dependent Protein Kinases
Concept	DNA Primers
Concept	Hindlimb Suspension
Concept	Genetic Predisposition to Disease
Concept	Receptors, Adrenergic, beta-3
Concept	Thermogenesis
Concept	Baccharis
Concept	Fluorescence Resonance Energy Transfer
Concept	Transcription Factor CHOP
Concept	Adiponectin
Concept	Sarcoplasmic Reticulum Calcium-Transporting ATPases
Academic Article	American Thyroid Association Guide to investigating thyroid hormone economy and action in rodent and cell models.
Academic Article	Characterization of the nuclear factor-kappa B responsiveness of the human dio2 gene.
Academic Article	Neuronal hypoxia induces Hsp40-mediated nuclear import of type 3 deiodinase as an adaptive mechanism to reduce cellular metabolism.
Academic Article	Effects of rexinoids on thyrotrope function and the hypothalamic-pituitary-thyroid axis.
Academic Article	Triplets! Unexpected structural similarity among the three enzymes that catalyze initiation and termination of thyroid hormone effects.
Academic Article	Expression of uncoupling protein 1 in mouse brown adipose tissue is thyroid hormone receptor-beta isoform specific and required for adaptive thermogenesis.
Academic Article	Thyroid hormone--sympathetic interaction and adaptive thermogenesis are thyroid hormone receptor isoform--specific.
Academic Article	Hypoxia-inducible factor induces local thyroid hormone inactivation during hypoxic-ischemic disease in rats.
Academic Article	Treatment with thyroxine restores myelination and clinical recovery after intraventricular hemorrhage.
Academic Article	Hypothyroidism and hypertension: fact or myth? - Authors' reply.
Academic Article	Role of the type 2 iodothyronine deiodinase (D2) in the control of thyroid hormone signaling.
Academic Article	The History and Future of Treatment of Hypothyroidism.
Academic Article	A novel pathway regulates thyroid hormone availability in rat and human hypothalamic neurosecretory neurons.
Academic Article	Cold exposure rapidly induces virtual saturation of brown adipose tissue nuclear T3 receptors.
Academic Article	Coordination of hypothalamic and pituitary T3 production regulates TSH expression.
Academic Article	Type 2 deiodinase at the crossroads of thyroid hormone action.
Academic Article	Agouti-related protein (AGRP) has a central inhibitory action on the hypothalamic-pituitary-thyroid (HPT) axis; comparisons between the effect of AGRP and neuropeptide Y on energy homeostasis and the HPT axis.
Academic Article	The Foxo1-Inducible Transcriptional Repressor Zfp125 Causes Hepatic Steatosis and Hypercholesterolemia.
Academic Article	Wnt signaling regulates mitochondrial physiology and insulin sensitivity.
Academic Article	Early Developmental Disruption of Type 2 Deiodinase Pathway in Mouse Skeletal Muscle Does Not Impair Muscle Function.
Academic Article	Dexamethasone reduces energy expenditure and increases susceptibility to diet-induced obesity in mice.
Academic Article	Adaptive activation of thyroid hormone and energy expenditure.
Academic Article	Type 2 iodothyronine selenodeiodinase is expressed throughout the mouse skeleton and in the MC3T3-E1 mouse osteoblastic cell line during differentiation.
Academic Article	Perilipin promotes hormone-sensitive lipase-mediated adipocyte lipolysis via phosphorylation-dependent and -independent mechanisms.
Academic Article	The thyroid hormone-inactivating deiodinase functions as a homodimer.
Academic Article	The role of thyroid hormone and brown adipose tissue in energy homoeostasis.
Academic Article	Thyroid hormone and the neuroglia: both source and target.
Academic Article	Evidence of UCP1-independent regulation of norepinephrine-induced thermogenesis in brown fat.
Academic Article	A Common DIO2 Polymorphism and Alzheimer Disease Dementia in African and European Americans.
Academic Article	Hormonal regulation of malic enzyme and glucose-6-phosphate dehydrogenase in brown adipose tissue.
Academic Article	Of rats and men: thyroid homeostasis in rodents and human beings - Authors' reply.
Academic Article	Thyroid Hormone Signaling in Male Mouse Skeletal Muscle Is Largely Independent of D2 in Myocytes.
Academic Article	Quantitation of brown adipose tissue perfusion in transgenic mice using near-infrared fluorescence imaging.
Academic Article	The type 2 iodothyronine deiodinase is essential for adaptive thermogenesis in brown adipose tissue.
Academic Article	Responsiveness to thyroid hormone and to ambient temperature underlies differences between brown adipose tissue and skeletal muscle thermogenesis in a mouse model of diet-induced obesity.
Academic Article	New insights into thyroid hormone replacement therapy.
Academic Article	Inactivation of the adrenergic receptor ß2 disrupts glucose homeostasis in mice.
Academic Article	Thyroid function disturbance and type 3 iodothyronine deiodinase induction after myocardial infarction in rats a time course study.
Academic Article	Absence of thyroid hormone activation during development underlies a permanent defect in adaptive thermogenesis.
Academic Article	Systemic Thyroid Hormone Status During Levothyroxine Therapy In Hypothyroidism: A Systematic Review and Meta-Analysis.
Academic Article	LXRs regulate the balance between fat storage and oxidation.
Academic Article	Is a Normal TSH Synonymous With "Euthyroidism" in Levothyroxine Monotherapy?
Academic Article	Treatment of hypothyroidism: possibilities on the horizon.
Academic Article	Thyroid hormone activation by type 2 deiodinase mediates exercise-induced peroxisome proliferator-activated receptor-? coactivator-1a expression in skeletal muscle.
Academic Article	Regulation of thyroid hormone activation via the liver X-receptor/retinoid X-receptor pathway.
Academic Article	Cognitive decline following incident and preexisting diabetes mellitus in a population sample.
Academic Article	Disruption of beta3 adrenergic receptor increases susceptibility to DIO in mouse.
Academic Article	Optimal response of key enzymes and uncoupling protein to cold in BAT depends on local T3 generation.
Academic Article	Thyroid hormone signaling in energy homeostasis and energy metabolism.
Academic Article	Selective proteolysis of human type 2 deiodinase: a novel ubiquitin-proteasomal mediated mechanism for regulation of hormone activation.
Academic Article	Cellular and molecular basis of deiodinase-regulated thyroid hormone signaling.
Academic Article	Induction of Type 2 Iodothyronine Deiodinase After Status Epilepticus Modifies Hippocampal Gene Expression in Male Mice.
Academic Article	The type 2 deiodinase A/G (Thr92Ala) polymorphism is associated with decreased enzyme velocity and increased insulin resistance in patients with type 2 diabetes mellitus.
Academic Article	Metabolic effects of thyroid hormones-beyond traditional prospects.
Academic Article	Ubc6p and ubc7p are required for normal and substrate-induced endoplasmic reticulum-associated degradation of the human selenoprotein type 2 iodothyronine monodeiodinase.
Academic Article	Deiodinases: implications of the local control of thyroid hormone action.
Academic Article	Thyroxine induced transformation in sarcoplasmic reticulum of rabbit soleus and psoas muscles.
Academic Article	betaAR signaling required for diet-induced thermogenesis and obesity resistance.
Academic Article	Mice lacking Pctp /StarD2 exhibit increased adaptive thermogenesis and enlarged mitochondria in brown adipose tissue.
Academic Article	Substrate-induced down-regulation of human type 2 deiodinase (hD2) is mediated through proteasomal degradation and requires interaction with the enzyme's active center.
Academic Article	Mice with impaired extrathyroidal thyroxine to 3,5,3'-triiodothyronine conversion maintain normal serum 3,5,3'-triiodothyronine concentrations.
Academic Article	Thyroid hormone-related regulation of gene expression in human fatty liver.
Academic Article	Perinatal deiodinase 2 expression in hepatocytes defines epigenetic susceptibility to liver steatosis and obesity.
Academic Article	Bacterial lipopolysaccharide (LPS)-induced type 2 iodothyronine deiodinase (D2) activation in the mediobasal hypothalamus (MBH) is independent of the LPS-induced fall in serum thyroid hormone levels.
Academic Article	Atypical expression of type 2 iodothyronine deiodinase in thyrotrophs explains the thyroxine-mediated pituitary thyrotropin feedback mechanism.
Academic Article	Feeding and metabolism in mice lacking pituitary adenylate cyclase-activating polypeptide.
Academic Article	Effects of hypothyroidism on brown adipose tissue adenylyl cyclase activity.
Academic Article	Endoplasmic reticulum-associated degradation of the human type 2 iodothyronine deiodinase (D2) is mediated via an association between mammalian UBC7 and the carboxyl region of D2.
Academic Article	Inhibition of the type 2 iodothyronine deiodinase underlies the elevated plasma TSH associated with amiodarone treatment.
Academic Article	For some, L-thyroxine replacement might not be enough: a genetic rationale.
Academic Article	Tissue-specific inactivation of type 2 deiodinase reveals multilevel control of fatty acid oxidation by thyroid hormone in the mouse.
Academic Article	Hypothyroidism.
Academic Article	Maternal inheritance of an inactive type III deiodinase gene allele affects mouse pancreatic ß-cells and disrupts glucose homeostasis.
Academic Article	Absence of myocardial thyroid hormone inactivating deiodinase results in restrictive cardiomyopathy in mice.
Academic Article	Pathophysiological relevance of deiodinase polymorphism.
Academic Article	Adaptive thermogenesis in hummingbirds.
Academic Article	Neuropeptide Y1 and Y5 receptors mediate the effects of neuropeptide Y on the hypothalamic-pituitary-thyroid axis.
Academic Article	Triumphs of the thyroid despite lesser conversion.
Academic Article	Does Sex Bias Play a Role for Dissatisfied Patients With Hypothyroidism?
Academic Article	The type II deiodinase is retrotranslocated to the cytoplasm and proteasomes via p97/Atx3 complex.
Academic Article	Covering the base-pairs in iodothyronine deiodinase-1 biology: holes remain in the lineup.
Academic Article	Thyroid hormone replacement therapy: three 'simple' questions, complex answers.
Academic Article	Central role of brown adipose tissue thyroxine 5'-deiodinase on thyroid hormone-dependent thermogenic response to cold.
Academic Article	A Transgenic Mouse Model for Detection of Tissue-Specific Thyroid Hormone Action.
Academic Article	Disruption of type 2 iodothyronine deiodinase activity in cultured human glial cells by polybrominated diphenyl ethers.
Academic Article	Guidelines for the treatment of hypothyroidism: prepared by the american thyroid association task force on thyroid hormone replacement.
Academic Article	Impaired metabolic effects of a thyroid hormone receptor beta-selective agonist in a mouse model of diet-induced obesity.
Academic Article	The iodothyronine selenodeiodinases are thioredoxin-fold family proteins containing a glycoside hydrolase clan GH-A-like structure.
Academic Article	Deubiquitination of type 2 iodothyronine deiodinase by von Hippel-Lindau protein-interacting deubiquitinating enzymes regulates thyroid hormone activation.
Academic Article	Combined treatment with caffeic and ferulic acid from Baccharis uncinella C. DC. (Asteraceae) protects against metabolic syndrome in mice.
Academic Article	Coupling between Nutrient Availability and Thyroid Hormone Activation.
Academic Article	Lipopolysaccharide induces type 2 iodothyronine deiodinase in the mediobasal hypothalamus: implications for the nonthyroidal illness syndrome.
Academic Article	Intracellular conversion of thyroxine to triiodothyronine is required for the optimal thermogenic function of brown adipose tissue.
Academic Article	Triiodothyronine amplifies norepinephrine stimulation of uncoupling protein gene transcription by a mechanism not requiring protein synthesis.
Academic Article	Myocardial Inactivation of Thyroid Hormones in Patients with Aortic Stenosis.
Academic Article	Serum bile acids are higher in humans with prior gastric bypass: potential contribution to improved glucose and lipid metabolism.
Academic Article	An inside job.
Academic Article	Type 1 iodothyronine deiodinase is a sensitive marker of peripheral thyroid status in the mouse.
Academic Article	The chemical chaperones tauroursodeoxycholic and 4-phenylbutyric acid accelerate thyroid hormone activation and energy expenditure.
Academic Article	Regional physiological adaptation of the central nervous system deiodinases to iodine deficiency.
Academic Article	Thyroid hormone deiodinases and cancer.
Academic Article	Ubiquitination-induced conformational change within the deiodinase dimer is a switch regulating enzyme activity.
Academic Article	Defending plasma T3 is a biological priority.
Academic Article	Epicardial adipose tissue has a unique transcriptome modified in severe coronary artery disease.
Academic Article	Reawakened interest in type III iodothyronine deiodinase in critical illness and injury.
Academic Article	Human type 3 iodothyronine selenodeiodinase is located in the plasma membrane and undergoes rapid internalization to endosomes.
Academic Article	The small polyphenolic molecule kaempferol increases cellular energy expenditure and thyroid hormone activation.
Academic Article	Prevalent polymorphism in thyroid hormone-activating enzyme leaves a genetic fingerprint that underlies associated clinical syndromes.
Academic Article	Mice with targeted disruption of the Dio2 gene have cold-induced overexpression of the uncoupling protein 1 gene but fail to increase brown adipose tissue lipogenesis and adaptive thermogenesis.
Academic Article	Differential effects of central leptin, insulin, or glucose administration during fasting on the hypothalamic-pituitary-thyroid axis and feeding-related neurons in the arcuate nucleus.
Academic Article	Metal Coordinated Poly-Zinc-Liothyronine Provides Stable Circulating Triiodothyronine Levels in Hypothyroid Rats.
Academic Article	A TRbeta-selective agonist confers resistance to diet-induced obesity.
Academic Article	The thyroid hormone-inactivating type III deiodinase is expressed in mouse and human beta-cells and its targeted inactivation impairs insulin secretion.
Academic Article	Sonic hedgehog-induced type 3 deiodinase blocks thyroid hormone action enhancing proliferation of normal and malignant keratinocytes.
Academic Article	Deiodinase-mediated thyroid hormone inactivation minimizes thyroid hormone signaling in the early development of fetal skeleton.
Academic Article	Bile acids induce energy expenditure by promoting intracellular thyroid hormone activation.
Academic Article	Type 2 iodothyronine deiodinase is highly expressed in germ cells of adult rat testis.
Academic Article	Minireview: cracking the metabolic code for thyroid hormone signaling.
Academic Article	The human type 2 iodothyronine deiodinase is a selenoprotein highly expressed in a mesothelioma cell line.
Academic Article	Distinct subcellular localization of transiently expressed types 1 and 2 iodothyronine deiodinases as determined by immunofluorescence confocal microscopy.
Academic Article	[Basedow-Graves' disease: analysis of various parameters in the prognosis of remission after clinical treatment].
Academic Article	Activation and inactivation of thyroid hormone by deiodinases: local action with general consequences.
Academic Article	Thyroid function in critically ill patients.
Academic Article	New insights into the variable effectiveness of levothyroxine monotherapy for hypothyroidism.
Academic Article	The Hedgehog-inducible ubiquitin ligase subunit WSB-1 modulates thyroid hormone activation and PTHrP secretion in the developing growth plate.
Academic Article	ß(1) Adrenergic receptor is key to cold- and diet-induced thermogenesis in mice.
Academic Article	Cloning and functional characterization of an uncoupling protein homolog in hummingbirds.
Academic Article	Corticosterone inhibits uncoupling protein gene expression in brown adipose tissue.
Academic Article	Differential effects of refeeding on melanocortin-responsive neurons in the hypothalamic paraventricular nucleus.
Academic Article	Differences in hypothalamic type 2 deiodinase ubiquitination explain localized sensitivity to thyroxine.
Academic Article	Metabolic instability of type 2 deiodinase is transferable to stable proteins independently of subcellular localization.
Academic Article	Spared bone mass in rats treated with thyroid hormone receptor TR beta-selective compound GC-1.
Academic Article	Type 2 Deiodinase Disruption in Astrocytes Results in Anxiety-Depressive-Like Behavior in Male Mice.
Academic Article	Endoplasmic reticulum stress decreases intracellular thyroid hormone activation via an eIF2a-mediated decrease in type 2 deiodinase synthesis.
Academic Article	Loss of Mpzl3 function causes various skin abnormalities and greatly reduced adipose depots.
Academic Article	Transcriptional and posttranscriptional mechanisms in uncoupling protein mRNA response to cold.
Academic Article	Disruption of thyroid hormone activation in type 2 deiodinase knockout mice causes obesity with glucose intolerance and liver steatosis only at thermoneutrality.
Academic Article	Crossing the hurdles of thyroid hormone receptor-a activation.
Academic Article	Chronic cardiac-specific thyrotoxicosis increases myocardial beta-adrenergic responsiveness.
Academic Article	Type 2 deiodinase expression is induced by peroxisomal proliferator-activated receptor-gamma agonists in skeletal myocytes.
Academic Article	Effects of thyroid hormone administration and estrogen deficiency on bone mass of female rats.
Academic Article	Type 2 deiodinase polymorphism causes ER stress and hypothyroidism in the brain.
Academic Article	Severe and mild neonatal hypothyroidism mediate opposite effects on Leydig cells of rats.
Academic Article	Biochemistry, cellular and molecular biology, and physiological roles of the iodothyronine selenodeiodinases.
Academic Article	Epicardial adipose tissue: emerging physiological, pathophysiological and clinical features.
Academic Article	Paracrine signaling by glial cell-derived triiodothyronine activates neuronal gene expression in the rodent brain and human cells.
Academic Article	In vivo dimerization of types 1, 2, and 3 iodothyronine selenodeiodinases.
Academic Article	S-nitrosoglutathione reductase-dependent PPAR? denitrosylation participates in MSC-derived adipogenesis and osteogenesis.
Academic Article	The use of recombinant human thyrotropin produced by Chinese hamster ovary cells for the preparation of immunoassay reagents.
Academic Article	Cellular and structural biology of the deiodinases.
Academic Article	The E3 ubiquitin ligase TEB4 mediates degradation of type 2 iodothyronine deiodinase.
Academic Article	Mice lacking brain-type creatine kinase activity show defective thermoregulation.
Academic Article	Possible mechanism of action of cholesterol enriched diet on the thyroid.
Academic Article	Expression patterns of WSB-1 and USP-33 underlie cell-specific posttranslational control of type 2 deiodinase in the rat brain.
Academic Article	An Online Survey of Hypothyroid Patients Demonstrates Prominent Dissatisfaction.
Academic Article	Scope and limitations of iodothyronine deiodinases in hypothyroidism.
Academic Article	Cardiac expression of human type 2 iodothyronine deiodinase increases glucose metabolism and protects against doxorubicin-induced cardiac dysfunction in male mice.
Academic Article	Cracking the code for thyroid hormone signaling.
Academic Article	The Deiodinase Trio and Thyroid Hormone Signaling.
Academic Article	Amiodarone and thyroid physiology, pathophysiology, diagnosis and management.
Academic Article	Adenosine 3',5'-monophosphate and thyroid hormone control of uncoupling protein messenger ribonucleic acid in freshly dispersed brown adipocytes.
Academic Article	Thyroid hormone receptor beta-specific agonist GC-1 increases energy expenditure and prevents fat-mass accumulation in rats.
Academic Article	Perilipin regulates the thermogenic actions of norepinephrine in brown adipose tissue.
Academic Article	Peroxisome proliferator activator receptor gamma coactivator-1 expression is reduced in obesity: potential pathogenic role of saturated fatty acids and p38 mitogen-activated protein kinase activation.
Academic Article	3,5,3'-Triiodothyronine actively stimulates UCP in brown fat under minimal sympathetic activity.
Academic Article	[Dopaminergic and somatostatinergic pathways decrease serum thyrotropin in rats bearing the 256-Walker mammary carcinoma].
Academic Article	Hepatic Inactivation of the Type 2 Deiodinase Confers Resistance to Alcoholic Liver Steatosis.
Academic Article	Paradigms of Dynamic Control of Thyroid Hormone Signaling.
Academic Article	Thyroid hormone inhibits lung fibrosis in mice by improving epithelial mitochondrial function.
Academic Article	Urgent need for further research in subclinical hypothyroidism.
Academic Article	The Swinging Pendulum in Treatment for Hypothyroidism: From (and Toward?) Combination Therapy.
Academic Article	Sustained Release T3 Therapy: Animal Models and Translational Applications.
Academic Article	Patient Context and Thyrotropin Levels Are Important When Considering Treatment of Subclinical Hypothyroidism.
Academic Article	Higher Caloric Exposure in Critically Ill Patients Transiently Accelerates Thyroid Hormone Activation.
Academic Article	Levothyroxine treatment and cholesterol in hypothyroidism.
Academic Article	We All Know We Need Them, We Hope They Are Coming, But When?
Academic Article	Liothyronine and Desiccated Thyroid Extract in the Treatment of Hypothyroidism.
Academic Article	Thyroid hormone stimulation of osteocalcin gene expression in ROS 17/2.8 cells is mediated by transcriptional and post-transcriptional mechanisms.
Academic Article	Individualized Therapy for Hypothyroidism: Is T4 Enough for Everyone?
Academic Article	Human Type 1 Iodothyronine Deiodinase (DIO1) Mutations Cause Abnormal Thyroid Hormone Metabolism.
Academic Article	Challenges in Developing Recommendations Based on Low-Quality Evidence in Thyroid Guidelines.
Academic Article	Iodine Deficiency Increases Fat Contribution to Energy Expenditure in Male Mice.
Academic Article	Temporal Pole Responds to Subtle Changes in Local Thyroid Hormone Signaling.
Academic Article	Evidence-Based Use of Levothyroxine/Liothyronine Combinations in Treating Hypothyroidism: A Consensus Document.
Academic Article	Assessment of children in the autistic spectrum disorder that carry the Thr92Ala-DIO2 polymorphism.
Academic Article	Accelerating functional gene discovery in osteoarthritis.
Academic Article	Deiodinases and the Metabolic Code for Thyroid Hormone Action.
Academic Article	Evidence-Based Use of Levothyroxine/Liothyronine Combinations in Treating Hypothyroidism: A Consensus Document.
Academic Article	Letter to the Editor from Idrees and Bianco: "Treatment of Thyroid Dysfunction and Serum Lipids: A Systematic Review and Meta-analysis".
Academic Article	Sociodemographic Disparities in the Treatment of Hypothyroidism: NHANES 2007-2012.
Academic Article	Use of Statins Among Patients Taking Levothyroxine: an Observational Drug Utilization Study Across Sites.
Academic Article	Comparative Effectiveness of Levothyroxine, Desiccated Thyroid Extract, and Levothyroxine+Liothyronine in Hypothyroidism.
Academic Article	Neonatal thyroxine activation modifies epigenetic programming of the liver.
Academic Article	Publisher Correction: Accelerating functional gene discovery in osteoarthritis.
Academic Article	Thyroid Hormone Levels During Hospital Admission Inform Disease Severity and Mortality in COVID-19 Patients.
Academic Article	Extended Absorption of Liothyronine from Poly-Zinc-Liothyronine: Results from a Phase 1, Double-Blind, Randomized, and Controlled Study in Humans.
Academic Article	Deiodinase-3 is a thyrostat to regulate podocyte homeostasis.
Academic Article	Response to Letter to the Editor From Bonnema et al: "Comparative Effectiveness of Levothyroxine, Desiccated Thyroid Extract, and Levothyroxine + Liothyronine in Hypothyroidism".
Academic Article	Brain Fog in Hypothyroidism: Understanding the Patient's Perspective.
Academic Article	Primary hypothyroidism and quality of life.
Academic Article	Heterozygote Advantage of the Type II Deiodinase Thr92Ala Polymorphism on Intrahospital Mortality of COVID-19.
Academic Article	Inactivation of Type 3 Deiodinase Results in Life-long Changes in the Brown Adipose Tissue Transcriptome in the Male Mouse.
Academic Article	The relevance of T3 in the management of hypothyroidism.
Academic Article	Suboptimal Thyroid Hormone Replacement Is Associated With Worse Hospital Outcomes.
Academic Article	Selpercatinib-Induced Hypothyroidism Through Off-Target Inhibition of Type 2 Iodothyronine Deiodinase.
Academic Article	Age Worsens the Cognitive Phenotype in Mice Carrying the Thr92Ala-DIO2 Polymorphism.
Academic Article	Multisensory Stimulation Improves Cognition and Behavior in Adult Male Rats Born to LT4-treated Thyroidectomized Dams.
Academic Article	T3 levels and thyroid hormone signaling.
Academic Article	Enhancing the Patient Voice: Quality of Life, Satisfaction, and Preference During Treatment of Hypothyroidism.
Academic Article	Serum Thyrotropin and Triiodothyronine Levels in Levothyroxine-treated Patients.
Academic Article	Different Hypothalamic Mechanisms Control Decreased Circulating Thyroid Hormone Levels in Infection and Fasting-Induced Non-Thyroidal Illness Syndrome in Male Thyroid Hormone Action Indicator Mice.
Concept	Ataxin-3
Concept	Forkhead Box Protein O1
Concept	Liver X Receptors
Concept	Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha
Concept	Zinc Finger Protein GLI1
Concept	Gene Editing
Concept	Elongin
Concept	Binge Drinking
Concept	Clustered Regularly Interspaced Short Palindromic Repeats
Concept	CRISPR-Cas Systems
Concept	Non-alcoholic Fatty Liver Disease
Grant	Thyroid-adrenergic synergism and adaptive thermogenesis
Grant	Selenodeiodinase processing by the proteasome system
Academic Article	Axonal T3 uptake and transport can trigger thyroid hormone signaling in the brain.
Academic Article	Are We Restoring Thyroid Hormone Signaling in Levothyroxine-Treated Patients With Residual Symptoms of Hypothyroidism?
Academic Article	Demographic, Healthcare Access, and Dietary Factors Associated With Thyroid Hormone Treatments for Hypothyroidism.
Academic Article	Levothyroxine Treatment Adequacy and Formulation Changes in Patients with Hypothyroidism: A Retrospective Study of Real-World Data from the United States.
Academic Article	The D2D3 form of uPAR acts as an immunotoxin and may cause diabetes and kidney disease.
Academic Article	The Effects of Patient Characteristics on the Management of Subclinical Hypothyroidism: A Survey of Faculty and Trainees.
Academic Article	Emerging Therapies in Hypothyroidism.
Academic Article	Gene polymorphisms and thyroid hormone signaling: implication for the treatment of hypothyroidism.
Academic Article	Localized T3 production modifies the transcriptome and promotes the hepatocyte-like lineage in iPSC-derived hepatic organoids.
Academic Article	A Cross-Sectional Analysis of Cardiovascular and Bone Health Care Utilization During Treatment With Thyroid Hormone.
Academic Article	Sustained Pituitary T3 Production Explains the T4-mediated TSH Feedback Mechanism.
Academic Article	The Relationship Between Work Relative Value Unit Awareness and Work Relative Value Unit Accumulation Among Physicians.
Academic Article	Impaired T3 uptake and action in MCT8-deficient cerebral organoids underlie Allan-Herndon-Dudley syndrome.
Academic Article	Editorial: (Re)defining hypothyroidism: the key to patient-centered treatment.
Academic Article	Thyroid hormone homeostasis in levothyroxine-treated patients: Findings from ELSA-Brasil.

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